Martin Selmayr, senior aide to European Commission President Jean-Claude Juncker, responded to the resignations by tweeting the word "bauernopfer" - German for the sacrifice of a pawn in chess.
Senior party figures have cautioned against any immediate leadership challenge, saying it would cause only further disruption as Britain prepares to start the Brexit talks as early as June 19.
The attacks only put May under more scrutiny for national security decisions she made during her tenure as Home Secretary, a role she held for six years in the government of her predecessor, David Cameron.
A stronger majority would have given May more ability to resist "hardline pro-Brexit factions in her party", and would have let her offer better terms to the EU. "May sought a mandate". "May's departure from Downing St.is remorseless".
To form a government, a political party needs to reach the majority mark of 326 seats.
Instead of opting for a post-election shuffle, the Prime Minister retained key figures in her cabinet. It is still unclear if this is a formal arrangement or if it simply means the DUP has agreed to consider support vote-by-vote.
European officials are anxious that the weaker position of the Conservatives make a breakdown in negotiations more likely. The DUP is a socially conservative group that opposes abortion and same-sex marriage and had links to Protestant paramilitary groups during Ireland's sectarian "Troubles".
The woman did, however, insist Mrs May stays on as Prime Minister for the sake of "continuity" but warned her she treads a fine line with the negotiations. "We can still do this", he continued.
"Last night's reported turn out of young people in this election is a testament to the work of students' unions and a clear sign students and young people care about politics and care about the future of our society", Shakira Martin, the union's president-elect, told FE Week.
United Kingdom bookmakers had speculated overnight who the next prime minister could be. "That is always what I have tried to do in my time as a member of Parliament".
So the Labour and Liberal Democrat majority in the House of Lords - which May cowed into authorizing the start of the Brexit talks in February - can reject the deal that a minority Conservative government produces.
The Conservative leader has been warned her days are numbered after calling Thursday's vote three years early, only to lose her majority in parliament. Therefore it remains to be seen for how long she can hang onto power.
"May fights to remain PM", said the front page of the Daily Telegraph, while the Times of London said: "May stares into the abyss".